• Inheritance of the SLICK1 allele of PRLR in cattle

    11 days ago - By Animal Genetics

    Summary
    The slick-hair phenotype in cattle is due to one of a series of mutations in the prolactin receptor that cause truncation of the C-terminal region of the protein involved in JAK2/STAT5 activation during prolactin signaling. Here we evaluated whether the inheritance of the SLICK1 allele, the first slick mutation discovered, is inherited in a fashion consistent with Hardy-Weinberg equilibrium. It was hypothesized that any deleterious effect of inheriting the allele on embryonic or fetal function would result in reduced frequency of the allele in offspring. A total of 525 Holstein and...
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