• Alternative polyadenylation events differ dramatically between Tongcheng and Large White pigs in response to PRRSV infection

    1 month ago - By Animal Genetics

    Summary
    Alternative polyadenylation is a widespread post-transcriptional regulation mechanism that increases the biological complexity of transcriptome and proteome. However, it is unclear whether APA regulation plays a role in genetic resistance to porcine reproductive and respiratory syndrome virus. Here, we reported genome-wide APA regulation of porcine alveolar macrophages in PRRSV-resistant Tongcheng pigs and PRRSV-susceptible Large White pigs upon PRRSV infection. Using 3′ mRNA sequencing strategy, we detected 75 981 high-quality APA sites in porcine alveolar macrophages of TC and LW...
    Read more ...