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Mutation c.−379 C> T in DGAT1 affects intramyocellular lipid content by altering MYOD1 binding affinity
15 days ago - By Animal Genetics
Abstract
Intramuscular fat is one of the most important indexes of pork taste quality. Diacylglycerol acyltransferase 1 , belonging to the acyl-coenzyme A: DGAT enzymes family, is a rate-limiting enzyme responsible for the final step of triglyceride synthesis. It is involved in TG storage in skeletal muscle; however, the underlying mechanism is not well understood. This study aimed to uncover functional mutations that can influence DGAT1 expression and consequently affect IMF deposition in pork. Two experimental groups containing individuals with high and low IMF content (6.23 ± 0.20 vs...
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