• Altered fibrinogen level and fibrin clot structure in myostatin homozygous mutant pig

    2 monthes ago - By Animal Genetics

    Abstract
    Obesity is associated with increased serum fibrinogen level. Myostatin , a strong inhibitor of skeletal muscle growth, is recognized as a potential target for obesity. However, the effect of MSTN inhibition on fibrinogen is not largely known. The objective of the present study was to explore fibrinogen levels after MSTN inhibition. Fibrinogen levels and the fibrin clot structure of MSTN homozygous knockout and wild-type pigs were investigated. The protein expression of fibrinogen in the serum and liver of KO pigs decreased greatly (1.6-fold loss for serum and 2.5-fold loss for...
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