• A large deletion in the Plasminogen gene is associated with ligneous membranitis in a Maltese dog

    15 days ago - By Animal Genetics

    Summary
    Ligneous membranitis/conjunctivitis is a hereditary disorder caused by a congenital plasminogen deficiency. In veterinary medicine, LM has rarely been reported in Golden Retrievers, Yorkshire Terriers, Doberman Pinschers and Scottish Terriers. In the latter breed, an A> T variation in an intron donor site of the PLG gene has been found to be the sole causative molecular defect reported to date in dogs. Owing to the absence of plasmin enzymatic clearance which in turn depends on the lack of its proenzyme plasminogen, fibrin deposits tend to accumulate in viscous membranes on the...
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