• The Asp298Asn polymorphism of melanocortin‐4 receptor in pigs: evidence for its potential effects on MC4R constitutive activity and cell surface expression

    1 month ago - By Animal Genetics

    Summary
    In humans and mice, melanocortin receptor 4 and melanocortin receptor accessory protein 2 can form a complex and control energy balance, thus regulating body weight and obesity. In pigs, a missense variant of MC4R has been suggested to be associated with growth and fatness; however, the effect of Asp298Asn substitution on MC4R function is controversial, limiting its application in animal breeding. Here we examined the effect of this polymorphism on MC4R constitutive activity, cell surface expression and signaling, and its interaction with MRAP2 in pigs. We found that: both pig MC4R...
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