• The first genome‐wide association study concerning idiopathic epilepsy in Petit Basset Griffon Vendeen

    21 days ago - By Animal Genetics

    Summary
    The dog breed Petit Basset Griffon Vendeen has a relatively high prevalence of idiopathic epilepsy compared to other dog breeds and previous studies have suggested a genetic cause of the disease in this breed. Based on these observations, a genome-wide association study was performed to identify possible epilepsy-causing loci. The study included 30 unaffected and 23 affected dogs, genotyping of 170K SNPs, and data analysis using plink and emmax. Suggestive associations at CFA13, CFA24 and CFA35 were identified with markers close to three strong candidate genes. However, subsequent...
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  • A genome‐wide association study reveals additive and dominance effects on growth and fatness traits in large white pigs

    21 days ago - By Animal Genetics

    Summary
    The dominance effect is a kind of non-additive effect due to the interaction between alleles at the same locus. Quantitative traits such as growth traits in farm animals have been found to be influenced by dominance effects. However, dominance effects are usually ignored in the genome-wide association study of complex traits for farm animals. In this study, we performed GWAS and genetic parameters estimation for the two traits age at 100 kg and backfat thickness at 100 kg of 3572 Large White pigs. The pigs were from three breeding farms of China and were genotyped by an in-house...
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